Myocardial energy metabolism in heart failure: Systematic review and meta-analysis of Phosphorus-31 magnetic resonance spectroscopy phosphocreatine/adenosine triphosphate ratio.

ABSTRACT:

Objective

Phosphorus-31 magnetic resonance spectroscopy (³¹P MRS) is the only non-invasive imaging modality that directly quantifies myocardial energy metabolism in vivo. While extensively studied, its readiness for clinical application in heart failure remains uncertain. This meta-analysis aimed to evaluate the association between myocardial phosphocreatine-to-adenosine triphosphate (PCr/ATP) ratio, measured by ³¹P MRS, and heart failure, as a step toward assessing its translational potential as a clinical biomarker.

Methods

We systematically reviewed studies published from January 1, 1990, to December 31, 2024, using PubMed, Embase, and Web of Science. Eligible studies included cohort studies and randomized controlled trials reporting PCr/ATP ratios in heart failure patien

SUBMITTER: Peng J 

PROVIDER: S-EPMC12818134 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature