Transcriptomic analysis of Crandell-Rees feline kidney cell infections with field and vaccine feline calicivirus strains.

ABSTRACT: Feline upper respiratory tract disease (URTD) is a significant health concern in crowded environments, such as catteries and shelters. Feline calicivirus (FCV), which is endemic in domestic cats, is a major contributor to URTD and can cause a range of diseases that vary in severity. Unlike many other caliciviruses, including human caliciviruses and noroviruses, FCV replicates efficiently in cell culture and is a well-established model for studying calicivirus-host cell interactions. In this study, RNA-sequencing was used to characterise host and viral transcription profiles in Crandell-Rees feline kidney (CRFK) cells infected with either the attenuated F9 vaccine strain or a virulent field strain associated with virulent systemic FCV (VS-FCV) disease. At six hours post-infection, both stra

SUBMITTER: Kwan E 

PROVIDER: S-EPMC12818158 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature