CXCR6⁺ T Cells Drive Immune Checkpoint Inhibitor Myocarditis.

ABSTRACT:

Background

Myocarditis is a severe complication of immune checkpoint inhibitors (ICIs). The major risk factor for ICI myocarditis is the use of combination ICI treatment, especially when relatlimab, a novel anti-LAG-3 (lymphocyte-activation gene 3) antibody, is combined with anti-PD-1 (programmed cell death protein 1) therapy. Although pathogenic T cells are necessary for ICI myocarditis, the specific signaling and T-cell populations that drive cardiac infiltration have not been fully elucidated, especially in setting of anti-LAG-3/PD-1 treatment.

Methods

We used VigiBase, an international pharmacovigilance database, to assess the risk of myocarditis with anti-LAG-3 compared with other ICI treatment regimens. We identified a mouse model of LAG-3/PD-1-associated ICI myocardit

SUBMITTER: Munir AZ 

PROVIDER: S-EPMC12818167 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature