Perimenopause as an obesogenic sensitive period: Contributions to elevated cardiovascular risk.

ABSTRACT:

Background

Perimenopause, encompassing the period of progressive menstrual irregularity preceding a woman's final menstrual cycle and extending 12 months thereafter, is associated with an acceleration in atherosclerotic cardiovascular disease (CVD) risk, attributable in part to redistribution of body fat. During perimenopause, even in the context of minimal-to-modest weight gain, women experience an expansion of visceral adipose tissue. Concomitantly, women often experience a reduction in gluteofemoral subcutaneous adipose tissue. This pattern of fat redistribution is associated with a greater prevalence of CVD risk factors and a higher incidence of CVD events. Here we present a case of disproportionate weight gain and fat redistribution in a woman newly initiating a long-acting in

SUBMITTER: Manning ME 

PROVIDER: S-EPMC12818170 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature