Kidney Tubule Secretion and AKI After Cardiac Surgery.

ABSTRACT:

Introduction

Endogenous measures of impaired kidney tubule secretion are associated with kidney function decline. Whether they associate with future acute kidney injury (AKI) risk is unclear.

Methods

In 397 participants of the Reasons for Geographic and Racial Differences in Stroke study who underwent coronary artery bypass graft (CABG) surgery (mean age: 66 years, 29% female), we examined the association of a summary secretion score of 11 endogenous secretion markers (measured at a median 5.5 years before CABG) with AKI risk following CABG, adjusting for confounders including estimated glomerular filtration rate (eGFR) and albuminuria.

Results

A total of 177 participants developed AKI (≥ 0.3 mg/dl or 1.5× creatinine increase) following CABG. Individuals who developed

SUBMITTER: Gutierrez OM 

PROVIDER: S-EPMC12818208 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature