Identification of predictive factors for clinical remission and comparison of 3 definitions in Japanese patients with severe asthma treated with biologics.

ABSTRACT:

Background

The definition and predictive factors of clinical remission (CR) in patients with severe asthma are unclear.

Objective

We sought to elucidate the remission rate among patients and predictive factors and concordance rates of CR among 3 definitions.

Methods

From July 2009 to November 2024 at Jikei University Hospital, 126 patients who received treatment with biologics for ≥ 12 months were evaluated retrospectively.

Results

Biologics was given to 40 men and 86 women for ≥ 12 months. Initially, 34, 42, 27, 21, and 2 patients received omalizumab, mepolizumab, benralizumab, dupilumab, and tezepelumab, respectively. After treatment, among all patients, the following criteria were achieved: asthma control test score of ≥ 23 in 32% of patients, no exacerbatio

SUBMITTER: Numata T 

PROVIDER: S-EPMC12818223 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature