Myeloid AEG-1/MTDH drives inflammation and hepatocellular dysfunction in diet-induced steatohepatitis.

ABSTRACT: Astrocyte elevated gene-1 (AEG-1)/metadherin plays an important role in regulating lipid metabolism and inflammation in hepatocytes and promotes metabolic dysfunction-associated steatohepatitis (MASH). Myeloid cells, such as macrophages, play a key role in regulating inflammation. Here, we investigated the role of AEG-1 in myeloid cells in regulating high fat)/high sugar diet (HF/HSD)-induced MASH. Littermates of myeloid cell-specific AEG-1 knockout mice (AEG-1^ΔMAC) and AEG-1 floxed mice (AEG-1^fl/fl) were fed either a control diet or an HF/HSD for 20 weeks. Both male and female AEG-1^ΔMAC mice were significantly protected from MASH development compared with AEG-1^fl/fl mice. In control diet-fed mice, spatial transcriptomics analysis revealed inhibi

SUBMITTER: Raha S 

PROVIDER: S-EPMC12818226 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature