Choroidal Vascular Remodeling and Retinal Response After Aflibercept Loading in Diabetic Macular Edema.

ABSTRACT:

Purpose

To investigate choroidal changes after aflibercept treatment for diabetic macular edema (DME) and to assess their association with treatment response.

Design

A retrospective interventional cohort study.

Subjects

Thirty eyes from 30 patients who were injection-naïve for DME and received initial 5 monthly loading injections of aflibercept.

Methods

Choroidal and retinal changes after loading injections were analyzed using spectral-domain OCT with enhanced depth imaging (EDI-SD-OCT) and ultra-widefield indocyanine green angiography (UWF-ICGA). The correlation between choroidal and retinal changes, along with factors associated with a good treatment response, was investigated.

Main outcome measures

Changes in subfoveal choroidal thickness (sfCT), tota

SUBMITTER: Han YE 

PROVIDER: S-EPMC12818254 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature