Lung aeration and gas exchange in preterm infants developing moderate-to-severe bronchopulmonary dysplasia: a multicentre prospective study from the PATH-BPD cohort.

ABSTRACT:

Background

We lack data about the early evolution of lung pathophysiology in infants developing moderate-to-severe broncho-pulmonary dysplasia (msBPD). We aimed to describe lung aeration and gas exchange during the early phase of msBPD development and identify the critical moments at which they change.

Methods

Prospective, multicentre, cohort study performed in three European centres enrolling preterm (≤30 weeks' gestation) infants evaluated at 10, 21, 28 days (D) of life and 34 and 36 weeks (W) post-menstrual age, while receiving as little invasive ventilation as possible. Lung aeration was assessed with quantitative lung ultrasound. Pulse oximetry and transcutaneous blood gas measurements were used to calculate the SpO₂/FiO₂ and PtcO₂/FiO

SUBMITTER: De Luca D 

PROVIDER: S-EPMC12818268 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature