Interaction of serum zinc and copper status with fatty acid desaturases on incidence of type 2 diabetes in the EPIC-Potsdam study.

ABSTRACT:

Aims

To examine whether zinc (Zn) and copper (Cu) status influence the association of estimated delta-5 desaturase (D5D), delta-6 desaturase (D6D), and stearoyl-CoA desaturase-1 (SCD1) activities with type 2 diabetes (T2D) risk.

Methods

We used a nested case-cohort design within the EPIC-Potsdam Study (n = 1979; 447 incident T2D cases). Desaturase activities were estimated using erythrocyte fatty acids (FA): D5D (20:4n-6/20:3n-6), D6D (18:3n-6/18:2n-6), and SCD1 (16:1/16:0 [SCD1-16], 18:1/18:0 [SCD1-18]). We evaluated associations between desaturases and serum Zn or Cu, assessed interactions between serum Zn or Cu and desaturase activities in Cox regression models for T2D risk, and examined modification by Zn transporter SLC30A8 genetic variant and metal-related polygenic ri

SUBMITTER: Prada M 

PROVIDER: S-EPMC12818309 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature