Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening.

ABSTRACT:

Background

Excessive dietary salt intake increases vascular stiffness in humans, especially in salt-sensitive populations. While we recently suggested that the endothelial sodium channel (EnNaC) contributes to salt-sensitivity related endothelial cell (EC) and arterial stiffening, mechanistic understanding remains incomplete. This study therefore aimed to explore the role of EC-serum and glucocorticoid regulated kinase 1 (SGK1), as a reported regulator of sodium channels, in EC and arterial stiffening.

Methods and results

A mouse model of salt sensitivity-associated vascular stiffening was produced by subcutaneous implantation of slow-release deoxycorticosterone acetate (DOCA) pellets, with salt (1 % NaCl, 0.2 % KCl) administered via drinking water. Preliminary data showed t

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12818392 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature