<i>Shigella</i> OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome.

ABSTRACT: The NAIP-NLRC4 inflammasome senses pathogenic bacteria by recognizing the cytosolic presence of bacterial proteins such as flagellin and type III secretion system (T3SS) subunits. In mice, the NAIP-NLRC4 inflammasome provides robust protection against bacterial pathogens that infect intestinal epithelial cells, including the gastrointestinal pathogen Shigella flexneri. By contrast, humans are highly susceptible to Shigella, despite the ability of human NAIP-NLRC4 to robustly detect Shigella T3SS proteins. Why the NAIP-NLRC4 inflammasome protects mice but not humans against Shigella infection remains unclear. We previously found that human THP-1 cells infected with Shigella lose responsiveness to NAIP-NLRC4 stimuli, while

SUBMITTER: Turcotte EA 

PROVIDER: S-EPMC12818434 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature