Cellular multipoint adaptive technology for two-photon mesoscope.

ABSTRACT:

Significance

In mesoscopic imaging research in neuroscience, achieving high spatial resolution optical imaging across the entire field of view (FOV) remains critical. This directly determines whether researchers can precisely analyze the large-scale dynamic activities of neural circuits at the single-cell or even subcellular level. Consistent optical quality throughout the entire imaging FOV is essential to accurately capture the spatiotemporal patterns of neural activity across brain regions, thereby providing a powerful tool for understanding the circuit mechanisms underlying cognition, behavior, and disease at cellular and subcellular resolution in vivo.

Aim

This study aims to develop a technology that extends the imaging FOV in a two-photon mesoscope while enhanci

SUBMITTER: Chen S 

PROVIDER: S-EPMC12818465 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature