Hip osteoarthritis is not a risk factor for immune checkpoint inhibitor-induced inflammatory arthritis.

ABSTRACT:

Objective

To evaluate whether hip osteoarthritis (OA) is a risk factor for checkpoint inhibitor-induced inflammatory arthritis (ICI-IA).

Methods

Patients treated for thoracic cancers with ICI therapy and with a CT of the abdomen/pelvis within one month of ICI start were included; hip OA was graded from a coronal slice of the CT by a radiologist. Chart review determined the presence of ICI-IA and other immune related adverse events Those with Kellgren-Lawrence grade of 2 or higher in either hip on CT abdomen/pelvis were classified as having hip OA. Incidence rates of ICI-IA were calculated in patients with and without hip OA. Development of ICIIA and overall survival were compared by Kaplan-Meier curves and Cox proportional hazards.

Results

A total of 309 patients were

SUBMITTER: Fitzpatrick R 

PROVIDER: S-EPMC12818542 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature