A smoking-related plasma protein score and smoking-related cancer risk and mortality in ARIC.

ABSTRACT:

Background

Self-reported smoking may not fully capture individualized risk of smoking-related cancer. Circulating proteins may reflect biological consequences of smoking. Thus, we developed a score from smoking-related proteins and evaluated its association with smoking-related cancer.

Methods

This prospective cohort study included 10,563 participants aged 47-70 years in the Atherosclerosis Risk in Communities study. Plasma proteins were measured by SomaScan. The score was constructed from proteins associated with current smoking, packyears, and/or recent quitting identified by linear regression and elastic net regression. Cox regression was used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI). We confirmed the association in a case-cohort study in

SUBMITTER: Ru M 

PROVIDER: S-EPMC12818548 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature