Single Polysaccharide Dissolvable Microneedles for Painless Local Anesthesia: Fabrication, Characterization, and <i>In Vitro</i> Neuronal Imaging.

ABSTRACT: In recent years, microneedles (MNs) have shown high potential as drug delivery devices capable of administering different drugs in a simple, fast, and minimally invasive manner. Their ability to pierce the stratum corneum barrier heavily outweighs the inconveniences posed by conventional administration methods such as hypodermal injections, creams, or ointments. In this work, high-performance, single-component polysaccharide-based microneedles, viz. pullulan MNs, were produced by micromolding, aimed for transdermal delivery of lidocaine. These dissolvable MNs were able to sustain forces up to 1.5 N per needle without breakage. Their ability to overcome the stratum corneum was validated using excised human abdominal skin, with the MNs successfully reaching the dermis. The MN tips com

SUBMITTER: Leite JMSP 

PROVIDER: S-EPMC12818717 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature