New Chemotherapeutic Approaches to Treatment of Mesenchymal Triple-Negative Breast Cancer-Sensitive and Resistant to Cisplatin: Assessment of Cellular Response by Vibrational Microspectroscopy.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive type of breast tumor with the worst prognosis. New chemotherapeutic agents against TNBC are essential, aiming at a higher efficacy regarding cell growth inhibition and decreased angiogenesis and invasiveness coupled to lower acquired resistance and deleterious side effects. In this study, Raman and Fourier Transform Infrared (FTIR) microspectroscopies were applied to assess the impact of a trinuclear palladium-spermidine complex on human healthy and mesenchymal TNBC cells, with the results being compared to the clinically used drug cisplatin. To understand the metabolic impact of the drugs at the molecular level and identify the main biomarkers, unsupervised multivariate analysis of the data (Principal Component Analysis and Hiera

SUBMITTER: Martins CB 

PROVIDER: S-EPMC12818719 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature