Long-Term Cell-Membrane-Coated Ultrabright Nanospheres for Targeted Cancer Cell Imaging and Hydrophobic Drug Delivery.

ABSTRACT: Nanoparticle-based imaging agents have gained massive attention for the targeted cancer cell imaging of early stage disease diagnosis. Among these, organic dye-entrapped and -assembled nanoparticles have been considered as potential imaging agents. However, they are limited by poor brightness, low stability, low reproducibility, and selective surface engineering, which limit their translational potential. The molecular assembly of amphiphilic precursors and the chosen organic fluorophore can augment the brightness and stability of the engineered nanoimaging agents. Herein, we describe cancer cell-membrane-covered ICG-cellulose acetate nanospheres (180 nm) as biomimetic ultrabright nanoimaging agents for cancer cell imaging. Engineered biomimetic ultrabright imaging agents are compared with

SUBMITTER: Prasad R 

PROVIDER: S-EPMC12818752 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature