Lipid Shape as a Membrane Activity Modulator of a Fusogenic Antimicrobial Peptide.

ABSTRACT: An intriguing feature of many bacterial membranes is their prevalence of non-bilayer-forming lipids, such as the cone-shaped phosphatidylethanolamines and cardiolipins. Many membrane-active antimicrobial peptides lower the bilayer-to-hexagonal phase transition energy barrier in membranes containing such types of cone-shaped lipids. Here, we systematically studied how the molecular shape of lipids affects the activity of antimicrobial peptide EcDBS1R4, which is known to be an efficient fusogenic peptide. Using coarse-grained molecular dynamics simulations, we show the ability of EcDBS1R4 to form "hourglass-shaped" pores, which is inhibited by cone-shaped lipids. The abundance of cone-shaped lipids further correlates with the propensity of this peptide to oligomerize preferentially in antipa

SUBMITTER: Makowski M 

PROVIDER: S-EPMC12818768 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature