Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease.

ABSTRACT: Vascular diseases are powerful predictors of cardiovascular mortality, but they are typically under-recognized and undertreated. There is no effective treatment for either abdominal aortic aneurysm (AAA) or peripheral artery disease (PAD). Lipids are key molecules in cardiovascular diseases and good candidates for diagnosis, monitoring, and risk prediction; nonetheless, there is very limited information on the lipidomic profile of patients with AAA and PAD. We hypothesize that lipids can be used as important prognostic biomarkers of these diseases. To achieve this, we conducted a comprehensive C18 reversed-phase (RP) liquid chromatography-tandem mass spectrometry (LC-MS) lipidomic analysis of plasma from AAA and PAD patients undergoing open repair surgery, comparing their profiles with tho

SUBMITTER: Ferreira HB 

PROVIDER: S-EPMC12818829 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature