Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core-Shell Nanotransducers under Remotely Applied Magnetic Fields.

ABSTRACT: Magnetoelectric nanoparticles (MENPs), combining a magnetostrictive core with a piezoelectric shell, offer a promising route for remote-controlled biomedical applications by converting external magnetic fields into electric cues. However, the clinical translation of these materials remains limited due to the toxicity of high-performance piezoelectric materials, which typically contain lead. Previously, we developed lead-free MENPs comprising manganese ferrite oxide (MFO) core nanoparticles (NPs) coated with a Ba_0.85Ca_0.15Zr₀.₁Ti_0.9O₃ (BCZT) piezoelectric shell (MFO@BCZT). While these nanotransducers exhibit robust magnetic responsiveness and piezoelectric performance comparable to lead-based ceramics, their role in producing

SUBMITTER: Mendes MC 

PROVIDER: S-EPMC12818836 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature