Association of Circadian Rhythms With the Risk of Chronic Liver Disease: Findings From a Large Prospective Study.

ABSTRACT:

Introduction

The liver clock of hepatocytes is actively involved in regulating their proliferation, metabolism, oxidative stress response, and chronic liver disease (CLD) progression. However, the relationship between circadian rhythms and CLD remains poorly understood. This study aimed to examine the associations of circadian rhythms with metabolic dysfunction-associated steatotic liver disease, cirrhosis, and hepatocellular carcinoma.

Methods

This study included 94,006 participants from the UK Biobank. Circadian rhythms were assessed by a 7-day accelerometer by relative amplitude (RA), which indicates the difference between the most and least active periods. Cox regression and restricted cubic splines were used to evaluate the associations between circadian rhythms and CLD

SUBMITTER: Yang R 

PROVIDER: S-EPMC12818853 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature