Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).

ABSTRACT: Cortical dynamics underlie many cognitive processes and emerge from complex multiscale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool that can complement laboratory approaches. We present a model comprising eight somatosensory cortex subregions, 4.2 million morphological and electrically detailed neurons, and 13.2 billion local and mid-range synapses. In silico tools enabled reproduction and extension of complex laboratory experiments under a single parameterization, providing strong validation. The model reproduced millisecond-precise stimulus-responses, stimulus-encoding under targeted optogenetic activation, and selective propagation of stimulus-evoked activity to downstream areas. The model's direct correspondence with biol

SUBMITTER: Isbister JB 

PROVIDER: S-EPMC12818871 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature