PD-L2 Landscape and Correlation with Outcome: An Immunomic Analysis.

ABSTRACT:

Purpose

PD-L1 and PD-L2 are inhibitory ligands that interact with PD-1 receptors, enabling immune escape. Though PD-L1 has been extensively studied, much less is known about PD-L2. PD-L2 expression could lead to incomplete blockade of the PD-1 axis by anti-PD-L1 agents and also influence activity of anti-PD-1 agents.

Methods

We analyzed PD-L2 transcriptomic expression in a pan-cancer cohort (N=514; 489 patients with advanced/metastatic disease and clinical correlates available) for associations with immunomodulatory variables and outcome.

Results

The most common tumors were colorectal (27% [140/514]), pancreatic (11% [55/514]), and breast cancer (9.5% [49/514]). High PD-L2 expression (≥75^th RNA percentile rank) occurred in 19.5% (100/514) of patients; PD-L2

SUBMITTER: Patwari A 

PROVIDER: S-EPMC12818932 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature