Harnessing Fremy's salt for tyrosine-directed bioconjugations.

ABSTRACT: The current bioconjugation toolbox overwhelmingly comprises strategies that modify lysine and cysteine residues within proteins and peptides. Herein, we have leveraged Frémy's salt (potassium nitrosodisulfonate) to create an approach to bioconjugation predicated on the oxidation of tyrosine residues and the subsequent strain-promoted oxidation-controlled quinone ligation between the resultant 1,2-quinones and trans-cyclooctene-bearing cargoes.

SUBMITTER: Samuels ZV 

PROVIDER: S-EPMC12818945 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature