Bag-valve-endotracheal ventilation vs mechanical ventilation during cardiopulmonary resuscitation: a randomized experimental porcine study.

ABSTRACT:

Background

The impact of ventilation strategy during cardiopulmonary resuscitation (CPR) on downstream cardio-cerebral injury remains uncertain.

Methods

Animals were randomized to bag-valve-endotracheal ventilation (BVE) or mechanical ventilation (MV) in a standardized porcine CPR model. Ventilator settings were predefined and held constant. MV (Oxylog 3000 plus) was delivered in a controlled mode (Vt 6-8 mL·kg^-1, RR 10/min, I:E 1:2, PEEP 0 cmH₂O, P _peak limit 40 cmH₂O) with triggers disabled. BVE used a 1.6 L self-inflating bag connected to the ETT with a 40 cmH₂O pop-off valve; RR was guided at 10/min with a metronome targeting I:E 1:2 and no PEEP. Biomarkers for cardiac and cerebral injury were sampled at basel

SUBMITTER: Wang J 

PROVIDER: S-EPMC12819017 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature