Genetic variation associated with Marek's disease resistance and susceptibility in white leghorn chickens.

ABSTRACT: Despite of effective control by vaccination, Marek's disease virus (MDV) remains a significant threat to poultry health and productivity due to continued virus evolution, which drives the need to better understand host genetic factors underlying the resistance and susceptibility. Although great efforts have been made toward understanding the genetic resistance to MD, the genetic variations underlying varied susceptibility to MD remains poorly understood. In this study, we conducted a comprehensive genome-wide association and pathway enrichment analysis in chicken genomes of a MD-resistant inbred line 6 (LN6), a MD-susceptible inbred line 7 (SUS), and 6 recombinant congenic strains (RCS) derived from the lines 6 and 7. The incidence of MD in the RCS varied significantly, ranging from RCS-J

SUBMITTER: Dadousis C 

PROVIDER: S-EPMC12819034 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature