Characterization of individuals in whom body weight loss precedes diabetes onset: a retrospective, observational, longitudinal cohort study based on health checkup in Japan.

ABSTRACT: East Asians are known to develop diabetes mellitus at a lower body weight than Caucasians, potentially because of the different mechanisms underlying disease development. This study aimed to evaluate the variation in weight transition leading to diabetes onset in two subtypes of individuals (obese and non-obese) in a Japanese population. We conducted a retrospective, observational, longitudinal cohort study using health checkup data from 9, 260 participants in Japan. Individuals who developed diabetes within three years of the start of the observation period were excluded. Among the participants, 61.4% were men, and 259 developed diabetes. In the obesity group (body mass index [BMI] ≥25 kg/m²), the average BMI increased prior to the diabetes onset and subsequently decreased. Con

SUBMITTER: Shikata M 

PROVIDER: S-EPMC12819072 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature