Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel.

ABSTRACT: TRPM4 is a member of the transient receptor potential melastatin channel subfamily and functions as a Ca²⁺-activated monovalent-selective cation channel. It is widely expressed in various cells and tissues, where its activation depolarizes the plasma membrane potential and modulates various Ca²⁺-dependent biological processes. TRPM4 activity is potentiated by membrane phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P₂) and inhibited by cytosolic free adenosine triphosphate (ATP), allowing the channel to transition between different functional states in response to dynamic changes in cellular Ca²⁺, ATP and PtdIns(4,5)P₂ levels during signaling events. Here we present single-particle cryo-electron microscopy structures of human TRPM4 i

SUBMITTER: Teixeira-Duarte CM 

PROVIDER: S-EPMC12819144 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature