Association between the <i>PPARGC1A</i> Gly482Ser (rs8192678) polymorphism and endurance and power athlete status: a systematic review and meta-analysis.

ABSTRACT:

Background

Evidence on the association between the PPARGC1A Gly482Ser (rs8192678) polymorphism and elite athlete status is inconsistent, and a prior meta-analysis has used a genotype-merging approach that may bias results.

Objective

This systematic review and meta-analysis aimed to clarify the association between the PPARGC1A Gly482Ser (rs8192678) polymorphism and elite endurance and power athlete status.

Methods

A comprehensive literature search was conducted in PubMed, Web of Science, Embase, and Cochrane Library from inception to November 2025. Studies were included if they provided genotype frequency data for the PPARGC1A Gly482Ser polymorphism in elite endurance or power athletes and non-athlete controls. Fixed or random-effects models were u

SUBMITTER: Su W 

PROVIDER: S-EPMC12819181 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature