Advanced lung cancer inflammation index as a diagnostic indicator of bone turnover in osteoporotic fracture patients: a non-linear analysis.

ABSTRACT:

Background

Osteoporotic fractures (OPFs) are a major health concern in older adults and are strongly influenced by systemic inflammation and nutritional status. The Advanced Lung Cancer Inflammation Index (ALI), which combines body mass index, serum albumin, and neutrophil-lymphocyte ratio, has been linked to outcomes in chronic diseases, but its relationship with bone turnover markers (BTMs) in OPF remains unclear.

Methods

We analyzed 826 Chinese patients with OPFs admitted from 2017 to 2024. Bone formation and resorption were assessed using serum procollagen type I N-terminal propeptide (P1NP) and β-isomerized C-terminal telopeptide of type I collagen (β-CTX). ALI was log-transformed (lnALI) for analysis. Multivariable linear, generalized additive, and piecewise regression

SUBMITTER: Wang J 

PROVIDER: S-EPMC12819201 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature