Abdominal versus femoral subcutaneous fat gene expression in non-obese insulin resistant individuals.

ABSTRACT:

Introduction

Adipose tissue, once viewed primarily as an energy reservoir, is now recognized as an endocrine organ involved in various physiological functions, including energy balance and immune responses. Interestingly, recent insights suggest that not all overweight or obese individuals exhibit insulin resistance, guiding the focus towards depot-specific adipose gene expression and its metabolic implications. This pilot study investigates adipose depot-specific differences in gene expression in abdominal versus femoral subcutaneous adipose tissue (SAT) among non-obese, insulin-sensitive (IS) and insulin-resistant (IR) individuals, aiming to elucidate underlying mechanisms of metabolic dysfunction.

Methods

Seventeen non-obese participants scheduled for body contouring surg

SUBMITTER: Badran S 

PROVIDER: S-EPMC12819261 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature