Diabetes and tumor risk: a 23-year Danish national cohort study.

ABSTRACT:

Introduction

Diabetes mellitus is a recognized risk factor for cancer, yet the relationship between diabetes type and tumor risk remains unclear. This study aimed to estimate the overall tumor burden, including benign, premalignant, and malignant tumors, in individuals with type 1 and type 2 diabetes.

Methods

In this nationwide cohort study spanning 23 years (1999-2022), data on diabetes diagnosis, tumor development, and potential confounding variables were retrieved from multiple Danish national health registries. The cohort included more than 6.5 million individuals and 128,647 tumor events among individuals with diabetes. Crude and adjusted hazard ratios (HRs) were estimated using Cox regression.

Results

For individuals with type 1 diabetes, adjusted HRs indicated

SUBMITTER: Skovbjerg KF 

PROVIDER: S-EPMC12819280 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature