Comparison of the efficacy of antidiabetic agents in type 2 diabetes with MASLD: a network meta-analysis.

ABSTRACT:

Objective

To evaluate and compare the efficacy of different antidiabetic agents in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM).

Methods

We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science for relevant randomized controlled trials up to April 20, 2025. Primary outcomes were alanine aminotransferase (ALT), aspartate aminotransferase (AST), and triglycerides. Secondary outcomes included HDL, LDL, fasting plasma glucose (FPG), body mass index (BMI), and glycated hemoglobin (HbA1c). All statistical analyses were performed using R version 4.5.0.

Results

A total of 21 randomized controlled trials were included, covering 15 antidiabetic agents and involving 1,717 participant

SUBMITTER: Shao X 

PROVIDER: S-EPMC12819300 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature