Association between vancomycin therapeutic drug monitoring and improved clinical outcomes in critically ill patients receiving renal replacement therapy: a retrospective cohort study.

ABSTRACT:

Introduction

Vancomycin is commonly prescribed for serious infections in critically ill patients. A substantial proportion of these individuals present with renal impairment or develop acute kidney injury (AKI), and some may require renal replacement therapy (RRT). Different RRT modalities can substantially affect vancomycin pharmacokinetics, thereby posing challenges for individualized dosing. Although therapeutic drug monitoring (TDM) is recommended by clinical guidelines to optimize drug exposure, its association with mortality among critically ill patients undergoing RRT has not been well characterized.

Methods

This retrospective study used the MIMIC-IV database to identify adults with an initial ICU admission who received RRT within the first week and intravenous vancom

SUBMITTER: Peng H 

PROVIDER: S-EPMC12819319 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature