Comparative evaluation of static and dynamic 4D dose recalculations in pencil beam scanning proton therapy for oesophageal cancer.

ABSTRACT:

Background and purpose

The robustness of pencil beam scanned (PBS) proton plans to respiratory motion is often assessed in clinical practice by static 4D dose recalculations on selected 4D computed tomography (4DCT) phases. These capture anatomical variation but neglect interplay effects from sequential beam delivery. This study investigates these effects by comparing static and dynamic 4DDC for esophageal cancer patients.

Materials and methods

PBS proton plans following the PROTECT trial protocol were created for ten esophageal cancer patients from the open-access DIR-Lab 4DCT dataset. Plan robustness was evaluated by static and dynamic 4DDC, where the static approach accumulated the computed dose in individual 4DCT phases, while dynamic incorporated the temporal delivery s

SUBMITTER: Carizzoni LA 

PROVIDER: S-EPMC12819344 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature