Grandmaternal exercise improves the metabolic health of second-generation offspring generated from F1 females.

ABSTRACT:

Background

Maternal obesity during pregnancy can lead to increased risk for metabolic disease in offspring during adulthood, helping fuel the worldwide increase in obesity. Fortunately, studies in rodent models have established that female dams (F0) that perform voluntary wheel running exercise during pregnancy have first-generation (F1) offspring with improved glucose tolerance, suggesting a potential means to reduce the burden of generational metabolic disease transmission. We have shown that maternal exercise also affects F1 male offspring as sires, as their progeny (F2) have similarly improved metabolic health. Whether maternal exercise can affect F1 females in a manner that improves F2 offspring metabolism is not known. Here, we determined whether voluntary exercise by F0 gran

SUBMITTER: Alves-Wagner AB 

PROVIDER: S-EPMC12819348 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature