Exploring health consequences of Asthma-COPD overlap syndrome in a national study.

ABSTRACT: Asthma-COPD overlap syndrome (ACOS) represents a clinically significant yet under characterized respiratory phenotype. Comprehensive population-based assessments of ACOS-attributable burden, smoking dose-response relationships, phenotypic subtypes, and mechanistic pathways remain limited. Using 2023-2024 Behavioral Risk Factor Surveillance System data, we conducted 1:1 propensity score matching of 675 ACOS patients with controls without respiratory disease, balanced on 15 covariates including demographics, smoking exposure, BMI, and adverse childhood experiences. Outcomes encompassed health-related quality of life, functional disabilities, healthcare access, and health behaviors. Restricted cubic splines characterized smoking dose-response relationships. Latent class analysis identified AC

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12819372 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature