Spread of ST11-O13/KL47 hypervirulent carbapenem-resistant Klebsiella pneumoniae isolates in China.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a serious threat to global public health. Hypervirulent CRKP (Hv-CRKP) can cause life-threatening infections, with significantly higher virulence and mortality compared to classical CRKP. CRKP strains were isolated from hospitalized patients in Shandong Province, China, 2018-2023. We performed whole-genome sequencing and bioinformatic analyses to determine the multilocus sequence typing (MLST), capsular typing, antimicrobial resistance genes, virulence factors, and plasmid incompatibility (Inc) typing of these strains. 81 CRKP strains were collected, with the major carbapenemase genes were bla_NDM-1 (49.4%) and bla_KPC-2 (42.0%), and the major MLST types of ST11 (40.7%), ST45 (27.2%), and ST37 (19.8%). ST11-KP was

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12819373 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature