Antimalarial potential of curcumin derivatives evaluated through experimental and computational approaches.

ABSTRACT: Malaria remains a leading global health threat, with cases and deaths continually increasing each year. The rising number of drug-resistant cases further diminishes the effectiveness of current antimalarials, highlighting the need for potent and effective new compounds. Curcumin, a natural polyphenol, has been extensively studied for its therapeutic properties. However, its clinical use is limited by poor bioavailability. This study evaluates curcumin derivatives as potential antimalarial agents through in-silico screening and biological assessments, aiming to identify promising candidates for further development. For the first time, we reveal the multi-target mechanisms of action of these derivatives, focusing on their potential for immunomodulatory GSK-3β inhibition and haemin binding. T

SUBMITTER: Jamil SNH 

PROVIDER: S-EPMC12819389 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature