Development and preliminary validation of a predictive model for IgA nephropathy progression.

ABSTRACT: IgA nephropathy (IgAN), the most common primary glomerular disease worldwide, poses challenges in predicting progression at diagnosis-particularly in primary care. This study developed and validated a model to estimate 5-year renal survival and support early risk stratification for personalized management. A total of 1135 patients with biopsy-confirmed IgAN from Hangzhou Hospital of Traditional Chinese Medicine (2014-2017) were retrospectively enrolled and randomly assigned to training and internal validation cohorts in a 7:3 ratio. An external validation cohort comprising 352 patients was obtained from three independent centers (2015-2020). To identify robust prognostic variables, 1000 bootstrap samples were generated from the training set, each subjected to tenfold cross-validation to de

SUBMITTER: Wang J 

PROVIDER: S-EPMC12819421 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature