Comparative chemical and biological study of essential oils and n-hexane extracts of Thymus vulgaris and Thymus serpyllum (Lamiaceae).

ABSTRACT: This study presents a comparative chemical and biological evaluation of essential oils (EOs) and n-hexane extracts from Thymus vulgaris and Thymus serpyllum (Lamiaceae), alongside a reference commercial thyme oil. GC-MS analysis revealed significant differences in chemical composition among the samples, with T. serpyllum oil characterized by high thymol (74.47%) and caryophyllene (9.89%) content, while the commercial oil was dominated by carvacrol (80.37%). Cytotoxicity was assessed using the sulforhodamine B (SRB) assay on human skin fibroblast (HSF) cells to evaluate safety. Most samples exhibited low cytotoxicity (IC₅₀ > 100 µg/mL), except for T. serpyllum oil, which showed strong cytotoxicity (IC₅₀ = 18.48 µg/mL). Antidiabetic activity was evaluated via α-glucosid

SUBMITTER: AbdelRazek MMM 

PROVIDER: S-EPMC12819475 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature