Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila.

ABSTRACT: As aging is the primary risk factor for many chronic diseases, geroscience aims to target aging to delay age-related decline. Here, we identify Cyrene (dihydrolevoglucosenone), a sustainable, biocompatible solvent, as a novel geroprotective compound. Cyrene extends lifespan and healthspan in C. elegans, improving locomotor function and resistance to oxidative, thermal, osmotic, genotoxic, and proteotoxic stress. It also confers protection in neurodegenerative models of Alzheimer's, Parkinson's, and Huntington's disease. Cyrene is effective when delivered during development or early adulthood and requires administration before day 8 to extend longevity. Its benefits are independent of bacterial metabolism and at least partially independent of the FOXO transcription factor DAF-16. Importantl

SUBMITTER: AlOkda A 

PROVIDER: S-EPMC12819529 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature