Renalase deficiency suppresses hepatic triglyceride accumulation in the progression to MASLD/MASH by GAN diet in male mice.

ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern characterized by hepatic triglyceride (TG) accumulation, inflammation, and fibrosis. Renalase is known for its role in blood pressure regulation and catecholamine metabolism, but recent evidence suggests broader cytokine-like functions. Moreover, its involvement in MASLD remains unclear. In this study, we examined the effects of renalase deficiency on hepatic lipid metabolism in a Gubra Amylin NASH (GAN) diet-induced MASLD model using renalase knockout (KO) mice. Our results show that renalase KO mice exhibited reduced hepatic TG levels, accompanied by decreased gene and protein expression of Srebf1 involved in lipid synthesis, and lower gene expressions of antioxidant and fibrosis markers i

SUBMITTER: Okano Y 

PROVIDER: S-EPMC12819575 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature