Disrupted gray matter structural covariance networks in chronic insomnia disorder.

ABSTRACT:

Background

Chronic insomnia disorder (CID) is associated with changes in gray matter volume (GMV) and structural connectivity in several brain regions. However, alterations in the topological properties of the structural covariant network (SCN) remain poorly understood in CID.

Methods

Voxel-based morphometry and graph theory were applied to examine the topological characteristics of the GMV-based SCN in 82 patients with CID and 73 healthy controls. Group comparison of GMV and multiple regression with pittsburgh sleep quality index (PSQI) were conducted, with hamilton depression acale, hamilton depression scale, total intracranial volume, age, sex, and years of education as covariates. The brain SCN was constructed by thresholding Pearson correlations between the corrected GM

SUBMITTER: Li Z 

PROVIDER: S-EPMC12819604 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature