<i>Lactobacillus gasseri</i> CBT LGA2 alleviates muscle protein degradation and inflammation in immobilization-induced mouse.

ABSTRACT:

Introduction

Hindlimb immobilization rapidly induces skeletal muscle atrophy by reducing mechanical loading and accelerating proteolytic activity. This atrophy is further exacerbated by inflammatory signaling, which amplifies FOXO3a-driven expression of Atrogin-1 and MuRF1 and suppresses myogenic capacity. Emerging evidence suggests that specific probiotic strains may counteract these catabolic and inflammatory responses, prompting the evaluation of Lactobacillus gasseri CBT LGA2 (LGA2) in this study.

Methods

In the present study, five probiotic strains were screened in C2C12 myotubes and RAW264.7 macrophages to assess anti-proteolytic and anti-inflammatory activities. Whole-genome sequencing was conducted to determine genetic safety and functional gene profiles. In v

SUBMITTER: Jang JH 

PROVIDER: S-EPMC12819605 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature