Mitochondrial dysfunction and apoptotic signaling induced by the combined action of 2-aminoethyl dihydrogen phosphate and methyl-β-cyclodextrin in melanoma cells.

ABSTRACT: Melanoma cells exhibit remarkable metabolic adaptability, sustained by lipid enrichment and mitochondrial resilience that enable survival under stress. Disrupting these bioenergetic and structural supports may represent an effective therapeutic avenue. This study investigated the antiproliferative, pro-apoptotic, and mitochondrial effects of 2-aminoethyl dihydrogen phosphate (2-AEH₂P), alone and in combination with methyl-β-cyclodextrin (MβCD) in human (SK-MEL-28) and murine (B16-F10) melanoma cells, compared with normal human (FN1) and murine (L929) fibroblasts. Cell viability, proliferation index, mitochondrial membrane potential (ΔΨm), cell-cycle distribution, and apoptotic marker expression were evaluated following single and combined treatments. Morphological alterations we

SUBMITTER: Duarte de Oliveira TA 

PROVIDER: S-EPMC12819607 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature