High mortality and mechanical ventilation in COVID-19-associated pulmonary aspergillosis: insights from a two-center retrospective cohort study.

ABSTRACT:

Background

Studies on COVID-19-associated pulmonary aspergillosis (CAPA) have raised concerns regarding its high mortality rates. This study aims to assess the mortality of CAPA caused by Alpha and Omicron variants among intensive care unit (ICU) patients in China.

Methods

We enrolled 236 ICU patients admitted to Wuhan Huoshenshan Hospital from 4 January 2020, to 30 March 2022, during the Alpha variant epidemic, and 187 ICU patients admitted to Nanjing Jinling Hospital from 24 October 2022, to 19 January 2023, during the Omicron variant epidemic. We systematically collected clinical data for analysis, and all patients were confirmed to have SARS-CoV-2 infection through polymerase chain reaction (PCR) testing.

Results

The incidence of CAPA was 5.1% (12/236) during the

SUBMITTER: Zhong A 

PROVIDER: S-EPMC12819614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature