T1- and diffusion tensor-based fractal dimension of white and grey matter in multiple sclerosis.

ABSTRACT:

Introduction

Multiple sclerosis (MS) changes brain microstructure even at early disease stages, with changes detectable in normal-appearing white matter (NAWM) and grey matter (GM). Diffusion tensor imaging (DTI) is sensitive to such alterations, while fractal dimension (FD) provides complementary information on tissue complexity. We hypothesized that T1-based FD offers additional diagnostic value beyond DTI-derived metrics of tissue integrity, including fractional anisotropy (FA) and mean diffusivity (MD).

Methods

MRI data were acquired from 120 patients with relapsing-remitting MS and low mean Expanded Disability Status Scale (EDSS) scores, as well as 75 healthy control (HC) participants. FD, FA, and MD were quantified in global brain tissues and within white matter (WM) s

SUBMITTER: Mazur-Rosmus W 

PROVIDER: S-EPMC12819621 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature