Five differentially expressed proteins identified to serve as potential blood biomarkers for schizophrenia screening based on proteomics.

ABSTRACT:

Introduction

Schizophrenia is a multifactorial neuropsychiatric disorder characterized by a wide range of debilitating symptoms and relatively poor clinical outcome, bringing a huge burden of disease. However, the underlying pathological mechanism of this disease remains unclear. We aimed to use mass spectrometry to complete proteomics analysis to find biomarkers related to schizophrenia in peripheral blood, which can provide some biomarker for the pathology, diagnosis or treatment of schizophrenia and the focus of future research.

Methods

This study was a cross-sectional case-control study involving 46 patients with schizophrenia and 43 healthy controls. All subjects provided early morning fasting cubital venous blood, completed the collection of general demographic data an

SUBMITTER: Li R 

PROVIDER: S-EPMC12819645 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature